The Villa Esplanade is just a 4 minute walk from the main railway station. The former government district with the WCCB and the city’s excellent museum on Museumsmeile can be reached within a short time by bus and subway.
Cologne/Bonn Airport can be reached within 30 mintutes by airport shuttle bus via main railway station. The trade fairs in Cologne and Düsseldorf can easily and quickly be reached.
A 5 minute walk will take you into the center of Bonn where some interessing sights are awaiting you, e. g. the Beethovenhaus, the university and the park, or talk a walk to the Rhine, where you could go on a boat trip to the nearby Siebengebirge range.